Wahba, Alexander and Philipp, Alois and Behr, Renate and Birnbaum, Dietrich E. (1998) Heparin-coated equipment reduces the risk of oxygenator failure. ANNALS OF THORACIC SURGERY, 65 (5). pp. 1310-1312. ISSN 0003-4975,
Full text not available from this repository. (Request a copy)Abstract
Background. The development of an abnormal pressure gradient (APG) across the oxygenator is the most common cause of oxygenator failure during cardiopulmonary bypass. This necessitated changing the oxygenator in 4 patients in this series. A retrospective analysis of conditions predisposing to APG was performed. Methods. One thousand nine hundred fifty-nine operations with cardiopulmonary bypass were performed in adults. a range of membrane oxygenators was used subject to availability; 769 oxygenators were heparin-coated and 1,190 were uncoated, The pressure gradient across the oxygenator was measured under standardized conditions. An APG was defined as a gradient of greater than twice the mean. Results. An APG occurred in 44 uncoated and 3 heparin-coated oxygenators (p < 0.001). The mean age was higher for the APG group (p < 0.001). Fibrin deposits in the arterial line filter were noted in 45 patients. Logistic regression revealed that only fibrin deposition in the arterial line filter and the use of uncoated oxygenators were significantly associated with APG. Conclusions. We conclude that a heparin-coated oxygenator effectively prevents APG. This adds significantly to the safety of open heart operations. (C) 1998 by The Society of Thoracic Surgeons.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOPULMONARY BYPASS; ACTIVATION; GRANULOCYTE; COMPLEMENT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 May 2023 10:12 |
| Last Modified: | 23 May 2023 10:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49824 |
Actions (login required)
 |
View Item |
