Straub, Rainer H. and Dorner, Monika and Riedel, Jens and Kubitza, Marion and van Rooijen, Nico and Lang, Bernhard and Schoelmerich, Juergen and Falk, Werner (1998) Tonic neurogenic inhibition of interleukin-6 secretion from murine spleen caused by opioidergic transmission. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 274 (4). R997-R1003. ISSN 0363-6119,
Full text not available from this repository. (Request a copy)Abstract
The peripheral nervous system and the immune system were shown to have neurohumoral interactions. This study extends observations that demonstrated neuronal modulation of spontaneous interleukin-6 (IL-6) secretion in the spleen by norepinephrine (NE) and beta-endorphin. Spontaneous IL-6 secretion in vivo was markedly reduced by removal of macrophages with the clodronate technique. Furthermore, spontaneous IL-6 secretion was significantly inhibited at physiological concentrations of cortisol (10(-7) M). In the presence of 10(-7) M, cortisol, addition of norepinephrine (NE; 10(-5) M) and isoproterenol (10(-6) and 10(-5) M) significantly increased spontaneous IL-6 secretion (+20%; P = 0.0280, P = 0.0005, and P = 0.0050, respectively). In contrast, addition of beta-endorphin significantly inhibited spontaneous IL-6 secretion in the presence of 10(-7) M cortisol (-40%; 10(-11) M, P = 0.0410; 10(-10) M, P = 0.0005). To study the effect of endogenously released transmitters on spontaneous IL-6 secretion, spleen dices were electrically stimulated with 1, 5, 10, 50, and 100 Hz. Spontaneous IL-6 secretion was markedly reduced at a frequency of 10 Hz with 10(-7) M cortisol present (P < 0.0001). This indicates that the combination of nerve firing at 5-10 Hz and physiological cortisol conditions inhibits spontaneous IL-6 secretion. Inhibition of spontaneous IL-6 secretion from spleen macrophages is most probably due to a net inhibitory effect of opioidergic transmission under these conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INCREASES NOREPINEPHRINE TURNOVER; EXPRESSION; DEPLETION; TISSUE; RATS; murine spleen slices; macrophages; norepinephrine; beta-endorphin; inhibition of cytokines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Sep 2023 14:11 |
| Last Modified: | 05 Sep 2023 14:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49946 |
Actions (login required)
 |
View Item |
