Kurtz, Armin and Götz, Karl-Heinz and Hamann, Marlies and Kieninger, Martin and Wagner, Charlotte (1998) Stimulation of renin secretion by NO donors is related to the cAMP pathway. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 274 (4). F709-F717. ISSN 1931-857X,
Full text not available from this repository. (Request a copy)Abstract
This study aimed to characterize the cellular pathways along which nitric oxide (NO) influences the secretion of renin from the kidney. Using the isolated perfused rat kidney model, we found that the NO donor sodium nitroprusside (SNP) (1-30 mu mol/l) induced a prompt, concentration-dependent fourfold increase of basal renin secretion. The membrane-permeable cGMP analogs 8-bromo-cGMP and 8-(4-chlorophenylthio)-cGMP (8-pCPT-cGMP; each 5-50 mu mol/l) inhibited basal renin secretion and attenuated the stimulation of renin secretion by SNP. Conversely, the renin stimulatory effect of SNP was enhanced in the presence of the G kinase inhibitor Rp-8-CPT-cGMPS (10 mu mol/l). The renin stimulatory effect of SNP was amplified in nominally calcium-free perfusate and was abolished in the presence of angiotensin II (1 nmol/l). Renin secretion stimulated by SNP was clearly attenuated by the A kinase inhibitor Rp-8-CPT-cAMPS (25 mu mol/l). These findings indicate that the renin stimulatory effect of NO donors in renal juxtaglomerular cells cannot be explained by activation of G kinase and is also less likely to be causally related to the regulation of renin secretion by calcium. Because A kinase activity is required for the stimulation of renin secretion by SNP, it appears as if the renin stimulatory effect is causally related to the CAMP pathway controlling renin secretion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEPENDENT PROTEIN-KINASE; RENAL JUXTAGLOMERULAR CELLS; HEAT-STABLE ENTEROTOXIN; NITRIC-OXIDE SYNTHASE; PRESSURE CONTROL; GENE-EXPRESSION; RELAXING FACTOR; ANGIOTENSIN-II; RAT-KIDNEY; RELEASE; sodium nitroprusside; A kinase; G kinase; juxtaglomerular cells; adenosine 3 ',5 '-cyclic monophosphate |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Sep 2023 14:25 |
| Last Modified: | 05 Sep 2023 14:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/49947 |
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