Meining, Alexander and Bayerdoerffer, Ekkehard and Mueller, Petra and Miehlke, Stephan and Lehn, Norbert and Hoelzel, Dieter and Hatz, Rudolf and Stolte, Manfred (1998) Gastric carcinoma risk index in patients infected with Helicobacter pylori. VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 432 (4). pp. 311-314. ISSN 0945-6317,
Full text not available from this repository.Abstract
Epidemiological data show an association between Helicobacter pylori gastritis and gastric carcinoma. However, most people infected with H. pylori do not develop gastric cancer. We have therefore evaluated histological criteria indicating an increased risk for gastric cancer. H. pylori gastritis was investigated in 117 patients with small (O<2 cm) early gastric carcinomas and in 117 age-matched duodenal ulcer patients infected with H. pylori, who are known to have a low risk for developing gastric carcinoma, The results showed that infiltration with lymphocytes/plasma cells and infiltration with neutrophils predominating in the corpus, and intestinal metaplasia in antrum and corpus were associated with both types of gastric carcinoma (intestinal and diffuse, P<0.0001). If an index is computed by giving one point to each of these features, the predictive value for the presence of gastric carcinoma was 0.79 with a score of 2, and 0.94 with a score of 3 (all points on the index used). Application of this index might be a simple method of identifying patients infected with H. pylori and carrying a higher risk for gastric carcinoma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER; SECRETION; STOMACH; DISEASE; gastritis; cancer; Helicobacter pylori; cancer risk |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2023 08:57 |
| Last Modified: | 12 Sep 2023 08:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50003 |
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