Hobbhahn, Jonny and Schwall, B. and Hoerauf, K. and Koppenberg, J. and Englmeier, C. and Mrotzek, T. and Taeger, Kai (1998) Inhalational induction with sevoflurane in adults - efficacy, safety, patient preference and occupational exposure. ANASTHESIOLOGIE & INTENSIVMEDIZIN, 39 (3). pp. 118-124. ISSN 0170-5334,
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Efficacy, safety and patient acceptance of 8% sevoflurane as induction agent were studied in 84 non-premedicated adults. Additionally, occupational exposure to sevoflurane was measured in the induction room for a period of about 20 min. at three different constellations of the air conditioning and scavenging system. Loss of eye lash reflex occurred after 120 (80 - 310) seconds [median (range)] (stepwise adjustment of the vaporizer to 8 vol%), Intubation was performed after 6.0 (4.1 - 9.1) min at endtidal concentrations of 5.0 (4.0 - 6.6) vol% sevoflurane. There were no relevant respiratory events. Mean arterial pressure and heart rate were reduced by about 20%, 94% of the patients would choose sevoflurane induction again. Maximum exposure values("peak values") were 8.7 (1.4 - 72) ppm (anaesthetist) and 4.9 (0.8 - 37) ppm (anaesthesia nurse). Average exposure over 20 min, amounted to 4.4 (1.0 - 28.1) ppm and 2.5 (0.7 - 20) ppm, respectively. Short lasting peak values (> 40 ppm) were predominantely found when the face mask could not be properly fitted. Occupational exposure was not significantly higher without air-conditioning, but 5 times higher without the scavenging system. We conclude that induction of anaesthesia with 8% sevoflurane in adults is effective and safe and has a high patient preference. Occupational exposure for the staff is low if a proper fitting of the face mask can be assumed. The scavenging system is the crucial technical measure for reaching low exposure values during induction with sevoflurane.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANESTHESIA; ISOFLURANE; PROPOFOL; anaesthetics, inhalation; respiration; hemodynamics; patient compliance; occupational exposure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2023 09:19 |
| Last Modified: | 12 Sep 2023 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50024 |
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