Abels, Christoph and Karrer, Sigrid and Baeumler, W. and Goetz, E. and Landthaler, Michael and Szeimies, Rolf-Markus (1998) Indocyanine green and laser light for the treatment of AIDS associated cutaneous Kaposi's sarcoma. BRITISH JOURNAL OF CANCER, 77 (6). pp. 1021-1024. ISSN 0007-0920, 1532-1827
Full text not available from this repository. (Request a copy)Abstract
Indocyanine green (ICG) is clinically approved for the determination of liver function, cardiac output and plasma volume. In this pilot study, ICG was used as photosensitizer in combination with a diode laser to treat AIDS-associated Kaposi's sarcoma (KS) in three patients. Directly and up to 50 min after intravenous administration of ICG (2-4 mg kg(-1) body weight), KS (n = 57), mainly plaque-type, were irradiated using a diode laser (lambda(em) = 805 nm, 100 J cm(-2), 0.5-5 W cm(-2)) matching the absorption maximum. Complete remission of KS (n = 16) was achieved when irradiated 1-30 min after injection of the second dose of ICG (2 x 2 mg kg(-1) b.w., 30 min apart) with 3-5 W cm(-2) and 100 J cm(-2). Biopsies (n = 3) revealed necrosis of the tumour 24 h and complete remission 4 weeks after therapy. In general, systemic side-effects were not observed and cosmetic results were very good. However, hyperpigmentation occurred temporarily in lesions located on the lower extremities. These findings show that AIDS-associated KS can be effectively treated after photosensitization with ICG and subsequent irradiation with an appropriate diode laser. However, additional investigations need to elucidate the exact mechanism of action of ICG-mediated phototherapy and have to show the efficacy for the treatment of other highly vascularized solid tumours.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Kaposi's sarcoma; indocyanine green; tumour; laser; phototherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2023 09:35 |
| Last Modified: | 12 Sep 2023 09:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50033 |
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