Brand, Eva and Chatelain, Nathalie and Keavney, Bernard and Caulfield, Mark and Citterio, Lorena and Connell, John and Grobbee, Diederick E. and Schmidt, Susanne and Schunkert, Heribert and Schuster, Herbert and Sharma, Arya M. and Soubrier, Florent (1998) Evaluation of the angiotensinogen locus in human essential hypertension - A European study. HYPERTENSION, 31 (3). pp. 725-729. ISSN 0194-911X,
Full text not available from this repository. (Request a copy)Abstract
Different family and case-control studies support genetic linkage and association at the human angiotensinogen (AGT) locus with essential hypertension. To extend these previous observations, a European collaborative study of nine centers was set up to create a large resource of affected sibling pairs. The AGT locus was studied using a highly polymorphic dinucleotide repeat in the 3'-flanking region of the gene in 350 European families, comprising 630 affected sibling pairs. Statistical analyses using two different methods did not show any evidence for linkage either in the whole panel or in family subsets selected for severity or early onset of disease. Although several arguments from association studies suggest a role of the AGT gene in essential hyper-tension, this large family study did not replicate the initial linkage reported smaller studies. Our results highlight the difficulty of identifying susceptibility genes by linkage analysis in complex diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLOOD-PRESSURE; MET(235)->THR VARIANT; FAMILIAL HYPERTENSION; GENE; LINKAGE; POLYMORPHISM; ASSOCIATION; POPULATION; JAPANESE; WHITE; angiotensinogen; hypertension, essential; genetics; microsatellite repeats |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2023 10:51 |
| Last Modified: | 12 Sep 2023 10:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50047 |
Actions (login required)
 |
View Item |
