Langstein, J. and Michel, J. and Fritsche, J. and Kreutz, M. and Andreesen, Reinhard and Schwarz, H. (1998) CD137 (ILA/4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling. JOURNAL OF IMMUNOLOGY, 160 (5). pp. 2488-2494. ISSN 0022-1767,
Full text not available from this repository.Abstract
CD137 (ILA/4-1BB), a member of the TNF receptor family, was shown previously to inhibit proliferation and to induce apoptosis in T lymphocytes. In this study, we identify CD137 as a novel and potent monocyte activation factor, CD137 protein induces expression of IL-6, IL-8, and TNF-alpha, and inhibits expression of IL-10. Furthermore, CD137 differentially regulates expression of cell surface receptors, It induces expression of ICAM and reduces expression of Fc gamma RIII, while levels: of HLA-DR remain unchanged. CD137 also promotes adherence of monocytes. These effects of CD137 require immobilization of CD137 protein, indicating that they are mediated by cross-linking of a corresponding ligand/coreceptor expressed on monocytes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPLENIC B-CELLS; LYMPHOCYTE-PROLIFERATION; CROSS-LINKING; CD40 LIGAND; HUMAN 4-1BB; GROWTH; ILA; COSTIMULATION; INTERLEUKIN-8; SUPERFAMILY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Sep 2023 12:57 |
| Last Modified: | 12 Sep 2023 12:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50054 |
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