Naumann, Markus and Pirker, Walter and Reiners, K. and Lange, Klaus W. and Becker, Georg and Brücke, Thomas (1998) Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: A SPECT study using [I-123] epidepride and [I-123] beta-CIT. MOVEMENT DISORDERS, 13 (2). pp. 319-323. ISSN 0885-3185, 1531-8257
Full text not available from this repository.Abstract
There is increasing evidence that a dysfunction of the dopaminergic system may be involved in the pathogenesis of idiopathic dystonia. To visualize possible alterations of the pre-and postsynaptic side of striatal dopaminergic synapses, SPECT studies using the radiotracers [I-123] epidepride and [I-123] beta-CIT were performed in 10 patients with idiopathic cervical dystonia. Eleven age-and sex-matched subjects served as controls. [I-123] Epidepride is a new highly affine marker of D2 receptors, and [I-123] beta-CIT binds to dopamine transporters on dopaminergic nerve endings. [I-123] Epidepride binding was significantly reduced in both striata of dystonia patients compared with controls (p < 0.05). In contrast, striatal [I-123] beta-CTT uptake did not differ from controls. We conclude that dopaminergic dysfunction in idiopathic focal dystonia mainly involves postsynaptic mechanisms and suggest a disturbance of the indirect pathway of the motor circuit resulting in a disinhibited thalamocortical stimulation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADULT-ONSET DYSTONIA; F-18 DOPA UPTAKE; HUMAN BRAIN; BASAL GANGLIA; SEROTONIN TRANSPORTERS; SPASMODIC TORTICOLLIS; MOVEMENT-DISORDERS; PARKINSONS-DISEASE; NONHUMAN-PRIMATES; BINDING; dystonia; striatum; dopamine receptors; SPECT |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2023 07:52 |
| Last Modified: | 28 Feb 2023 07:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50062 |
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