Christgau, Michael and Palitzsch, Klaus-Dieter and Schmalz, Gottfried and Kreiner, U. and Frenzel, S. (1998) Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results. JOURNAL OF CLINICAL PERIODONTOLOGY, 25 (2). pp. 112-124. ISSN 0303-6979, 1600-051X
Full text not available from this repository. (Request a copy)Abstract
The aim of the present study was to monitor clinical, microbiological, medical, and immunological effects of non-surgical periodontal therapy in diabetics and healthy controls. 20 IDDM (insulin dependent, n=7) or NIDDM (non-insulin dependent, n=13) diabetic patients (median duration 11.5 years, range of HbA(1C): 4.4-10.6%) with moderate to advanced periodontal disease and 20 matched healthy control patients, were subjected to supragingival pretreatment and subsequent subgingival therapy. Periodontal examinations (API, PBI, BOP, PPD, PAL), microbiological examinations (culture), medical routine examinations, and immunological examinations (oxidative burst response of PMNs to TNF-cs and FMLP) were performed at baseline, 2 weeks after supragingival, and 4 months after subgingival therapy. 4 months after completion of non-surgical therapy, the following compared to baseline significant (p less than or equal to 0.05) changes (Delta) of clinical parameters (median) were found in diabetic patients versus control patients: Delta API (30.4% versus 36.3%), Delta PBI (22.9% versus 24.2%), Delta BOP (39.5% versus 46.9%). The median % per patient of pockets with PPD greater than or equal to 4 mm decreased from 41.9% to 28.3% in diabetics, and from 41.6% to 31.8% in controls. Microbiologically, similar reductions of periopathogenic bacteria were found in diabetics and controls. Neither periodontal data nor the oxidative burst response of PMNs showed any significant difference (p>0.05) between diabetics and control patients. In this study, periodontal therapy had no significant influence on medical data of diabetics. In conclusion, this study indicates that metabolically well-controlled diabetics might respond to non-surgical periodontal therapy as well as healthy control patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INSULIN-DEPENDENT DIABETICS; SUPRAGINGIVAL PLAQUE CONTROL; RESPIRATORY BURST ACTIVITY; METABOLIC CONTROL; SUBGINGIVAL MICROFLORA; JUVENILE DIABETICS; DISEASE EXPERIENCE; SERUM ANTIBODY; NEUTROPHIL; HYPERGLYCEMIA; diabetes mellitus; diabetes complications; periodontal disease/therapy; periodontal disease/microbiology; risk factors; neutrophils |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Oct 2023 06:51 |
| Last Modified: | 24 Oct 2023 06:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50111 |
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