Lohmann, Chris P. and Hoffmann, Elisabeth and Reischl, Udo (1998) Epidermal growth factor in the tear fluid: responsible for postoperative refraction and "haze" after PRK? OPHTHALMOLOGE, 95 (2). pp. 80-87. ISSN 0941-293X,
Full text not available from this repository.Abstract
Background: Corneal wound healing is of critical importance for the postoperative outcome of excimer laser PRK. Wound healing is a complex biological process that is well characterised at the microscopic level, but its regulation is poorly understood at the molecular level. Among Various cytokines, epidermal growth factor (EGF) plays an important role in superficial wound healing. The synthesis of EGF varies individually; therefore, by determining the EGF concentration in the tear fluid, patients with increased wound healing activity might be traced. Methods: In this study we measured the EGF concentration pre- and postoperatively in the tear fluid of 50 eyes using a ELISA test. The preoperative refraction was between -2.00 and -10.00 dioptres. The maximum follow-up was 6 months. Results: Preoperatively, in all eyes the EGF concentration in the tear fluid was between 0.2 and 1.7 ng/ml. In contrast, 1 week postoperatively, these values increased (0.21-22.50 ng/ml); 4 weeks postoperatively, the EGF concentration was in all eyes back to preoperative levels. In eyes with high EGF tear fluid concentration 1 week after surgery, refraction at 6 months was outside the intended correction of +/- 1.0 D. We could not find any correlation between EGF concentration and "corneal haze" Conclusions: EGF may play an important role in postoperative wound healing after excimer laser PRK. Investigations concerning a pharmaceutical control of EGF should be undertaken.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LASER PHOTOREFRACTIVE KERATECTOMY; 193-NM EXCIMER LASER; TOPICAL CORTICOSTEROIDS; SIGHTED EYES; EPITHELIAL-CELLS; SURFACE ABLATION; CORNEAL HAZE; FACTOR-ALPHA; MITOMYCIN-C; MYOPIA; excimer laser PRK; myopia; wound healing; epithelium; EGF |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Oct 2023 07:14 |
| Last Modified: | 24 Oct 2023 07:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50135 |
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