Pfeifer, Michael and Blumberg, Friedrich C. and Wolf, Konrad and Sandner, Peter and Elsner, Dietmar and Riegger, Günther A. J. and Kurtz, Armin (1998) Vascular remodeling and growth factor gene expression in the rat lung during hypoxia. RESPIRATION PHYSIOLOGY, 111 (2). pp. 201-212. ISSN 0034-5687
Full text not available from this repository.Abstract
Recent studies suggest that the vasoactive peptides endothelin-1 and -3 and the mitogens VEGF and PDGF-A and -B could be involved in the pathogenesis of hypoxic pulmonary hypertension. We were interested to investigate whether these peptides could also be involved in the vascular remodeling occurring during chronic hypoxia (10% oxygen; 1 and 3 weeks) in the rat. Hypoxia increased significantly; systolic right ventricular pressure and typical morphological signs of vascular remodeling were found. This was accompanied by increased ET-1 and the ET-3 mRNA expression after acute (6h,P<0.05) and chronic hypoxia of 1(P<0.05) and 3 weeks (P<0.05). In contrast, we found no effects of hypoxia on the gene expression of VEGF and PDGF-A and -B in the lung. Our findings indicate that ET-3 in addition to ET-1 could be involved in the process of hypoxia-induced vascular remodeling, whereas it appears less likely that the mitogens VEGF and PDGF-A and -B are essentially involved in the pathogenesis of hypoxic pulmonary hypertension.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PULMONARY-HYPERTENSION; ENDOTHELIAL-CELLS; NITRIC-OXIDE; SECRETION; PDGF; CHAIN; hypoxia, chronic, lung vascular remodeling; mammals, rat; mitogens, PDGF, VEGF; peptides, vasoactive, endothelin; pulmonary circulation, chronic hypoxia, vascular remodeling |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2023 10:17 |
| Last Modified: | 28 Feb 2023 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50139 |
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