Rothoerl, Ralf D. and Woertgen, Chris and Holzschuh, M. and Brehme, K. and Rueschoff, J. and Brawanski, A. (1998) Macrophage tissue infiltration, clinical symptoms, and signs in patients with lumbar disc herniation. A clinicopathological study on 179 patients. ACTA NEUROCHIRURGICA, 140 (12). pp. 1245-1248. ISSN 0001-6268, 0942-0940
Full text not available from this repository.Abstract
It is postulated that in addition to nerve-root compression, an inflammatory stimulus of the herniated lumbar disc is responsible for sciatic pain and radiculopathy. The clinical relevance of the histologically described inflammatory infiltrates is, however, not clearly defined [8, 22]. It was the aim of this study to assess the clinical relevance of inflammatory cells in herniated. lumbar disc specimens. The presence of inflammatory cells was examined immunohistochemically in routinely processed resection specimens of the lumbar disc. The histological results were compared to prospectively obtained clinical data. Disc specimens of 179 patients who under-went surgery for lumbar disc herniation were studied immunohistologically. Pre operatively each patient received a visual analogue scale for classification of the pain level and general clinical data were recorded prospectively. Varying amounts of inflammatory cells could be demonstrated in the resected disc tissue. In the statistical workup no statistically significant correlation between the histological evidence of macrophage infiltrates and the pain grading scale or the clinical data could be found. In our study there is no statistically significant correlation between macrophage infiltrates in herniated lumbar disc specimen and the obtained clinical data.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-BACK-PAIN; INTERVERTEBRAL DISC; PHOSPHOLIPASE A(2); NERVE; SPINE; lumbar disc herniation; inflammation; sciatic pain |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Oct 2023 09:15 |
| Last Modified: | 24 Oct 2023 09:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50161 |
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