Grimm, Daniela and Elsner, Dietmar and Schunkert, Heribert and Pfeifer, Michael and Griese, Daniel and Bruckschlegel, Günter and Muders, Frank and Riegger, Guenter A. J. and Kromer, Eckhard P. (1998) Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system. CARDIOVASCULAR RESEARCH, 37 (1). pp. 91-100. ISSN 0008-6363,
Full text not available from this repository. (Request a copy)Abstract
Objective: High dosages of catecholamines induce cardiomyocyte necrosis and interstitial fibrosis in rats. We investigated whether this initial damage is followed by the development of heart failure and assessed the particular role of the renin-angiotensin system using ramipril. Methods and Results: Following the administration of 0 mg or 150 mg isoproterenol/kg 6 groups of Wistar rats were followed for 2 or 16 weeks: Sham, isoproterenol, isoproterenol + ramipril. Isoproterenol induced significant increases of echocardiographically measured left ventricular end-diastolic posterior wall thickness and dimension, whereas ramipril treatment significantly attenuated these changes. Left ventricular end-diastolic pressure was markedly increased in isoproterenol-treated rats and normalized following ramipril. Isoproterenol rats were further characterized by hormonal activations including transient; elevations of plasma renin activity, aldosterone and cardiac angiotensin converting enzyme activity. Histomorphological characterization of isoproterenol-treated hearts demonstrated cardiomyocyte necrosis and reparative fibrosis. Ramipril treatment only slightly reduced the amount of necrosis as well as the expression of extracellular matrix proteins. Conclusions: In rats, a toxic dosage of isoproterenol caused characteristic myocardial damage that subsequently resulted in mild heart failure. Ramipril administration following isoproterenol was highly effective to attenuate hemodynamic and hormonal alterations as well as the development of left ventricular hypertrophy, but had only little influence on the expression of extracellular matrix proteins. Since angiotensin converting enzyme inhibition had no impact on the initial myocardial injury, the development of heart failure in this model seems to require functional integrity of the renin-angiotensin system. (C) 1998 Elsevier Science B.V.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PRESSURE-OVERLOAD HYPERTROPHY; CONVERTING ENZYME-INHIBITION; LEFT-VENTRICULAR HYPERTROPHY; MESSENGER-RNA EXPRESSION; INDUCED CARDIAC-FAILURE; MYOCARDIAL-INFARCTION; AORTIC-STENOSIS; HEMODYNAMICS; ACTIVATION; SURVIVAL; myocardium; heart failure; catecholamine; angiotensin converting enzyme inhibition; extracellular matrix proteins |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Oct 2023 09:42 |
| Last Modified: | 24 Oct 2023 09:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50175 |
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