Grell, Matthias and Becke, Florian M. and Wajant, Harald and Maennel, Daniela N. and Scheurich, Peter (1998) TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1. EUROPEAN JOURNAL OF IMMUNOLOGY, 28 (1). pp. 257-263. ISSN 0014-2980,
Full text not available from this repository.Abstract
Tumor necrosis factor (TNF) mediates its biological effects by binding to two distinct but homologous receptor molecules. The type 1 receptor (TNF-R1) has been shown to be essential and sufficient for most cellular responses to soluble TNF. In contrast, only limited data exist concerning the role of the type 2 receptor (TNF-R2) in TNF responses, both in vitro and in vivo. Here, we demonstrate by the use of thymocytes from TNF-R-deficient mice that the TNF-R2-dependent enhancement of proliferation and secretion of granulocyte-macrophage colony-stimulating factor is in fact mediated by TNF-R2 on its own, independent of cc-expression and/or stimulation of TNF-R1.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; ACTIVATION; CELLS; CYTOKINES; RESPONSES; DEFICIENT; APOPTOSIS; DEATH; MICE; TNF; thymocyte; knockout mouse |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Oct 2023 13:36 |
| Last Modified: | 24 Oct 2023 13:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50192 |
Actions (login required)
 |
View Item |
