Michel, Jan and Langstein, Joachim and Hofstaedter, Ferdinand and Schwarz, Herbert (1998) A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. EUROPEAN JOURNAL OF IMMUNOLOGY, 28 (1). pp. 290-295. ISSN 0014-2980,
Full text not available from this repository. (Request a copy)Abstract
CD137 (ILA/4-1BB) is a member of the tumor necrosis factor receptor family and regulates activation, proliferation and programmed cell death in T lymphocytes. Here we show the existence of a soluble form of CD137 (sCD137) of 16 kDa. sCD137 is released by activated lymphocytes, and in contrast to membrane-bound CD137, expression of sCD137 seems to be restricted to lymphocytes, sCD137 is generated by alternative splicing and two splice variants were identified. sCD137 is present at low levels in sera of some healthy donors (5/12; mean = 0.18 ng/ml) and is significantly enhanced in sera of patients with rheumatoid arthritis (12/12; mean = 3.58 ng/ml).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NERVE-GROWTH-FACTOR; FAS-MEDIATED APOPTOSIS; CD30 MOLECULE; HUMAN 4-1BB; ILA; PROLIFERATION; PROTEIN; LIGAND; rheumatoid arthritis; inflammation; cytokine receptor; human |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Oct 2023 13:40 |
| Last Modified: | 24 Oct 2023 13:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50193 |
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