Schwarzmann, Fritz and Jaeger, M. and Prang, N. and Wolf, H. (1998) The control of lytic replication of Epstein-Barr virus in B lymphocytes (Review). INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1 (1). pp. 137-142. ISSN 1107-3756,
Full text not available from this repository. (Request a copy)Abstract
Uncontrolled replication of a virus, which is harmful to the host is also disadvantageous to the virus. Most viruses cannot compete with the various immune mechanisms and become eliminated in the course of infection. Therefore, only the time between infection and eradication remains for these viruses to proliferate. A few viruses, like the Herpesviruses or the papillomaviruses, however, have developed a sophisticated strategy for persisting lifelong, usually asymptomatically in the host, hiding from the immune system and producing infectious progeny at the same time. This strategy depends on a separation of latency and the lyric replication, either by time due to differentiation-dependent mechanisms or by spatial separation as the result of different host cell types. Both are true for the Epstein-Barr virus (EBV). B cells and epithelial cells have a pivotal role in the life cycle of the virus. The former can become latently infected and are thought to be the virus reservoir in vivo, whereas the latter were shown to be permissive for lytic replication. However, replication of EBV in vivo is controlled primarily by host immune mechanisms selecting for cells that are not permissive for viral replication as the result of a particular set of transcription factors. These factors control the activity of the regulatory immediate-early genes and, in addition, lytic and latent cycle regulatory genes negatively interfere with each other and thus link cellular and viral gene regulatory mechanisms. Disturbance of both the immune surveillance as well as viral gene regulation may result in EBV-associated disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ORAL HAIRY LEUKOPLAKIA; BONE-MARROW TRANSPLANTATION; SWITCH GENE BZLF1; EPITHELIAL-CELLS; INFECTIOUS-MONONUCLEOSIS; NASOPHARYNGEAL CARCINOMA; NEGATIVE REGULATION; CARRIER STATE; C-ELEGANS; TRANSACTIVATOR; Epstein-Barr virus; replication; B lymphocytes; gene regulation; BZLF-1; EBNA |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Oct 2023 09:36 |
| Last Modified: | 31 Oct 2023 09:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50217 |
Actions (login required)
 |
View Item |
