Wahba, A and Rothe, G and Lodes, H and Barlage, S and Schmitz, G and Birnbaum, DE (1997) Predictors of blood loss after coronary artery bypass grafting. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 11 (7). pp. 824-827. ISSN 1053-0770,
Full text not available from this repository.Abstract
Objective: To assess the predictive value of variables possibly associated with blood loss after coronary artery bypass grafting(CABG). Design: A prospective study. Setting: A university hospital, Participants: Eighty-nine patients scheduled for elective CABG. Interventions: Blood samples were drawn before and after surgery. Chest tube drainage was measured hourly until removal of drains. Measurements and Main Results: Activation of coagulation and fibrinolysis, routine clotting tests, and expression of platelet surface antigens were analyzed using flow cytometry, A significant correlation was found among blood loss and activated partial thromboplastin time, fibrinogen, prothrombin fragment 1 + 2, D-dimers, platelet count, GPlb and P-selectin expression on platelets, use of internal thoracic artery, cross-clamp time, and thrombin-antithrombin ill complex. In a multiple regression model, glycoprotein (GP) Ib expression on platelets, platelet count, use of internal thoracic artery, and D-dimers were significantly associated with blood loss. Logistic regression analysis showed that GPlb and D-dimers predicted an increased blood loss with a positive predictive value of 73% and a negative predictive value of 91%. Conclusions: Postoperative D-dimers and GPlb expression may be useful to exclude nonsurgical causes in bleeding patients after CABG. Copyright (C) 1997 by W.B. Saunders Company.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOPULMONARY BYPASS; PLATELET DYSFUNCTION; FIBRINOLYSIS; ACTIVATION; SURGERY; AGGREGATION; HEPARIN; RELEASE; D-dimers; cardiac surgery; flow cytometry; platelet antigens |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50362 |
Actions (login required)
 |
View Item |
