Mühlbauer, B. and Luippold, G. and Vallon, V. and Spitzenberger, Folker and Russ, Hermann and Osswald, H. and Schömig, E. (1997) Disprocynium24 induces a dopamine-independent eukaliuric diuresis and natriuresis in the anaesthetized rat. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 356 (6). pp. 846-849. ISSN 0028-1298, 1432-1912
Full text not available from this repository.Abstract
In the anaesthetized rat, intravenous administration of the isocyanine 1,1'-diisopropyl-2,4'-cyanine (disprocynium24) ar doses up to 600 mu g/kg resulted in marked diuresis and natriuresis without affecting urinary potassium excretion, Fractional sodium excretion was increased over 10-fold indicating a high ceiling-diuretic action. The effects of disprocynium24 on renal function were accompanied by a dose-dependent reduction in heart rate (HR) and mean arterial blood pressure (MAP), Acute administration of 600 mu g/kg disprocynium24 decreased MAP by 25% and, in addition, caused a fall in glomerular filtration rate (GFR). Since i) disprocynium24 has been shown to interfere with urinary dopamine excretion (UDAV) and ii) dopamine has been implicated with the regulation of renal sodium excretion, we hypothesized that the effects of disprocynium24 might be mediated by its effects on renal dopamine handling. The following findings, however, argue against this hypothesis. First, administration of disprocynium24 in single doses up to 600 mu g/kg caused a diuresis and natriuresis, but did not significantly affect UDAV. Second, neither the systemic nor the renal response to disprocynium24 were markedly altered by pretreatment with the dopamine D-1- or D-2-receptor blockers SCH23390 (10 mu g.kg(-1).min(-1)) or S(-)sulpiride (15 mu g.kg(-1).min(-1)), respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSPORT; NORADRENALINE; INHIBITORS; RECEPTORS; isocyanines; disprocynium24; diuresis; natriuresis; dopamine SCH23390; S(-)sulpiride; anaesthetized rats |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Mar 2023 06:46 |
| Last Modified: | 02 Mar 2023 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50378 |
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