Grether-Beck, S. and Buettner, R. and Krutmann, J. (1997) Ultraviolet a radiation-induced expression of human genes: Molecular and photobiological mechanisms. BIOLOGICAL CHEMISTRY, 378 (11). pp. 1231-1236. ISSN 1431-6730, 1437-4315
Full text not available from this repository.Abstract
Increased gene expression as a consequence of environmental stress is typically observed in mammalian cells upon exposure to ultraviolet (UV) radiation. In previous years the cis-and trans-acting genetic elements responsible for gene induction by short wavelength UVC (< 280 nm) and intermediate wavelength UVB (280 - 320 nm) radiation have been well characterized. More recently, progress has also been made in understanding the mechanisms by which long wavelength UVA (320 - 400 nm) radiation induces transcriptional activation of human genes. From these studies it is now known that the photobiological as well as the molecular mechanisms involved in UVA radiation-induced gene expression differ from those previously identified for UVB-or UVC-induced gene expression. In particular, the reactive oxygen species singlet oxygen was found to serve as the primary effector in UVA radiation-induced gene expression by inducing a signal transduction cascade that depends on activation of transcription factor AP-2. These studies indicate a previously unrecognized role of AP-2 in the mammalian stress response.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRIPTION FACTOR AP-2; HIGH-DOSE UVA1; SINGLET OXYGEN; INDUCIBLE ENHANCER; HEME OXYGENASE; ACTIVATION; COLLAGENASE; ELEMENTS; FIBROBLASTS; MODULATION; ultraviolet A radiation; intercellular adhesion molecule-1; AP-2; singlet oxygen; polymorphous light eruption |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 07 Nov 2024 09:55 |
| Last Modified: | 07 Nov 2024 09:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50421 |
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