Gess, Bernhard and Wolf, Konrad and Pfeifer, Michael and Riegger, Günter A. J. and Kurtz, Armin (1997) In vivo carbon monoxide exposure and hypoxic hypoxia stimulate immediate early gene expression. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 434 (5). pp. 568-574. ISSN 0031-6768, 1432-2013
Full text not available from this repository.Abstract
This study aimed to examine the influence of acute tissue hypoxygenation on the expression of immediate early genes in different rat tissues. To this end male Sprague-Dawley rats were exposed to 0.1% carbon monoxide for 0.5, 1 and 6 h or to 9% oxygen for 6 h and mRNA levels for c-jun, c-fos, c-myc and EGR-1 were assayed by RNase protection in hearts, kidneys, livers and lungs. We found that hypoxia increased c-jun mRNA levels between twofold (lung) and eightfold (liver) in all organs examined; c-fos mRNA increased between threefold (lung) and 20-fold (heart); c-myc mRNA increased between twofold (lung) and sixfold (heart); and EGR-1 mRNA increased between twofold (lung) and sixfold (heart). Our findings suggest that acute tissue hypoxygenation is a general stimulus of the expression of immediate early genes in vivo. With regard to the sensitivity to hypoxia, organ differences appear to exist in that the lung is rather insensitive, whilst the heart is rather sensitive.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE CELLS; MESSENGER-RNA; C-FOS; ISCHEMIA; ERYTHROPOIETIN; HYPERTROPHY; PROTEIN; JUN; PROTOONCOGENES; acute tissue hypoxygenation; immediate early genes; carbon monoxide; erythropoietin |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2023 05:33 |
| Last Modified: | 30 Mar 2023 05:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50627 |
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