Koch, HJ and Raschka, C (1997) Interaction between physical activity and pharmacokinetics of cardiovascular drugs. HERZ KREISLAUF, 29 (7-8). pp. 219-223. ISSN 0046-7324,
Full text not available from this repository.Abstract
Sports Medicine and Sports Science have encouraged physical activity as a part of spare time for years. The influence of sport on the pharmacokinetics of drugs has therefore gained increasing importance. As a rule, physical activity may have an effect on different levels of LADME (Liberation, Absorption, Distribution, Metabolism, Elimination). However, it is difficult to assess the individual contribution of each level. The physico-chemical properties of a drug and the mode of administration are decisive factors which determine the overall influence of sport on pharmacokinetics. The clinical relevance of this effect is particularly due to the width of the therapeutic window and the type of administration. Drugs with a narrow therapeutic window such as digitalis or antiarrhythmic drugs may show substantially changed blood levels after physical activity due to altered absorption or metabolism Local administrations such as intramuscular injection or transdermal application depend on physical activity due to altered local perfusion. Experimental trials and simulations of concentration vs. time curves may improve safety and tolerability of longterm drug therapy in those who have integrated sport as part of their lifestyle.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | URINARY-EXCRETION; EXERCISE; ADJUSTMENTS; ABSORPTION; pharmacokinetics; physical exercise; simulation; blood levels |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50713 |
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