Schätzl, Hermann M. and Sieger, Emilia and Jilg, Wolfgang and Nitschko, Hans and Zachoval, Reinhart (1997) Variability of the hepatitis B surface protein in HBV-infected liver transplant recipients. JOURNAL OF BIOMEDICAL SCIENCE, 4 (4). pp. 146-154. ISSN 1021-7770, 1423-0127
Full text not available from this repository.Abstract
Variations in the major surface proteins (HBsAg) of hepatitis B virus (HBV) have been implicated in the high rate of reinfection in HBV-infected recipients of orthotopic liver transplantations (OLT), Sera from 6 OLT patients positive for HBsAg and from 3 recipients negative for it prior to transplantation were analyzed over several years, and 39 HBsAg sequences were compared. Despite anti-HBs immunoprophylaxis resulting in the disappearance of HBsAg, HBV DNA was detectable by a sensitive nested PCR in almost all sera, In 1 patient, a significant temporary shift in HBV subtypes was observed, indicating a mixed infection or the presence of multiple HBV populations in this patient; this was also true for other patients. Amino acid substitutions compared to wild-type HBV subtypes in 7 patients and variations within patients in 5 patients were detectable over time; the 'escape mutation' at amino acid position 145 was detected in 2 patients, Our data suggest that the high rate of reinfection in OLT recipients seems not to be associated with specific sequence variations in the major HBs gene, but shows a remarkable inter-and intraindividual variability, Obviously, no correlation between heterogeneity in this gene and clinical outcome was present.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECURRENT INFECTION; VIRUS-INFECTION; MOLECULAR-BASIS; C VIRUS; GENOME; CARRIERS; ANTIGEN; DNA; INDIVIDUALS; MUTANT; hepatitis B surface protein; genomic variability; escape mutation; liver transplantation; hepatitis B virus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Oct 2023 06:24 |
| Last Modified: | 25 Oct 2023 06:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50716 |
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