Lock, G. and Holstege, A. and Lang, B. and Schölmerich, Jürgen (1997) Gastrointestinal manifestations of progressive systemic sclerosis. AMERICAN JOURNAL OF GASTROENTEROLOGY, 92 (5). pp. 763-771. ISSN 0002-9270
Full text not available from this repository.Abstract
Management of patients with progressive systemic sclerosis requires a thorough gastroenterological examination and a profound knowledge of possible gastrointestinal manifestations of the disease. The esophagus is the gastrointestinal segment most often involved. Smooth muscle atrophy leads to a loss of esophageal peristalsis, a defect of the lower esophageal sphincter, and gastric hypomotility, thus predisposing to severe reflux esophagitis. A rational diagnostic approach includes standard manometry and endoscopy. The prevention of strictures is the main aim of therapeutic efforts that may consist of lifestyle changes, prokinetic drugs, long-term application of proton pump inhibitors, and, if inevitable, surgical intervention. Involvement of the small intestine and colon is less common but may lead to life-threatening complications like chronic pseudoobstruction or pneumatosis cystoides intestinalis. The main therapeutic options consist of antibiotics for bacterial overgrowth and nutritional supplementation. Recently, a preliminary study with octreotide yielded promising results. Anorectal dysfunction can lead to fecal incontinence or rectal prolapse.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESOPHAGEAL DYSFUNCTION; GASTROESOPHAGEAL REFLUX; CREST SYNDROME; ANORECTAL DYSFUNCTION; RADIONUCLIDE TRANSIT; MYOELECTRIC ACTIVITY; SCLERODERMA PATIENTS; PULMONARY-FUNCTION; RAYNAUDS DISEASE; SMOOTH-MUSCLE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 May 2024 07:50 |
| Last Modified: | 16 May 2024 07:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50829 |
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