Hunzelmann, N and Anders, S and Fierlbeck, G and Hein, R and Herrmann, K and Albrecht, M and Bell, S and Thur, J and Muche, R and AdelmannGrill, B and WehnerCaroli, J and Gaus, W and Krieg, T (1997) Systemic scleroderma - Multicenter trial of 1 year of treatment with recombinant interferon gamma. ARCHIVES OF DERMATOLOGY, 133 (5). pp. 609-613. ISSN 0003-987X,
Full text not available from this repository.Abstract
Objective: To confirm significant improvement of the skin score in systemic sclerosis by treatment with interferon gamma in a larger group of patients and to investigate on a molecular level the influence of interferon gamma on collagen type I messenger RNA expression. Design: Open, noncontrolled multicenter study. Setting: Five outpatient clinics specializing in the care of systemic scleroderma. Patients: Thirty-two patients suffering from the diffuse or limited form of systemic sclerosis and progressive disease were recruited; 20 patients finished the study. Intervention: Each patient received interferon gamma, 50 mu g subcutaneously 3 times a week for 1 year. Main Outcome Measure: Skin score, collagen type I messenger RNA in skin biopsy specimens. Results: The patients who completed the study showed an unchanged median skin score after 1 year of therapy. In addition, similar collagen type I messenger RNA levels were detected in skin biopsy specimens taken from involved skin before and after therapy in these patients. Conclusions: Treatment of systemic scleroderma with interferon gamma is associated with stabilization of the skin score and lack of worsening of visceral involvement.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROCOLLAGEN MESSENGER-RNA; GROWTH-FACTOR-BETA; COLLAGEN-SYNTHESIS; SKIN FIBROBLASTS; SCLEROSIS; EXPRESSION; INVITRO; FIBRONECTIN; CULTURE; CHAIN; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50835 |
Actions (login required)
 |
View Item |
