Ritthaler, Theresia and Schricker, Karin and Kees, Frieder and Krämer, Bernhard and Kurtz, Armin (1997) Acute hypoxia stimulates renin secretion and renin gene expression in vivo but not in vitro. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 272 (4). R1105-R1111. ISSN 0363-6119, 1522-1490
Full text not available from this repository.Abstract
This study aimed at examining the influence of acute hypoxia on renin secretion and renin gene expression in the kidney. To this end, male Sprague-Dawley rats were exposed to severe hypoxic stress (8% O-2) or to carbon monoxide (0.1% CO) for 6 h, and plasma renin activity (PRA) and renal renin mRNA levels were determined. PRA values increased from 3 to 13 and 10 ng angiotensin I.h(-1).ml(-1), and renin mRNA levels increased by 120 and 100% during hypoxia and CO, respectively. Lowering the Po-2 from 150 to 20 or 7 mmHg in the gas atmosphere of primary cultures of renal juxtaglomerular cells had no influence on renin secretion and renin gene expression after 6 and 20 h. Our findings thus suggest that both arterial and venous hypoxia can be powerful stimulators of renin secretion and renin gene expression in vivo. Because renal denervation did not prevent stimulation of the renin system by hypoxia, the effect could be indirectly mediated via the baroreceptor-macula densa mechanism. Another potential mediator of the effect could be circulating catecholamines, since we found that plasma norepinephrine increased from 0.7 to 1.5 and 2.4 ng/ml and plasma epinephrine increased from 0.3 to 1.4 and 2.7 ng/ml during hypoxia and CO inhalation, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANGIOTENSIN-CONVERTING ENZYME; ATRIAL-NATRIURETIC-FACTOR; RENAL NERVES; ALDOSTERONE SYSTEM; ENDOCRINE FUNCTION; ALTITUDE EXPOSURE; ALVEOLAR HYPOXIA; NORMAL HUMANS; RESPONSES; RAT; juxtaglomerular cells; catecholamines; carbon monoxide |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 May 2023 08:49 |
| Last Modified: | 11 May 2023 08:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50888 |
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