Frohlich, D and Eiber, RM and Jochum, M and Billing, A (1997) Perioperative pattern of peritoneal interleukin 8, tumour necrosis factor-alpha, and granulocyte elastase release in human secondary peritonitis. CYTOKINE, 9 (4). pp. 288-292. ISSN 1043-4666,
Full text not available from this repository.Abstract
Cytokine levels during infection and sepsis have been extensively studied in the past, In contrast to the excellent data on tumour necrosis factor alpha (TNF-alpha), interleukin 8 (IL-8), and polymorphonuclear (PMN) granulocyte elastase (PMN-E) concentrations in blood, little is known about cytokine and PMN-E levels in tissue or local fluids like abdominal exudate in secondary, purulent peritonitis of man, Therefore, the authors studied perioperative intra-abdominal levels of TNF-alpha, IL-8 and PMN-E in 21 patients with severe purulent peritonitis. The average pre-operative levels of TNF-alpha were 694 +/- 239 pg/ml in exudate and 26 +/- 6 pg/ml in plasma, for IL-8 100 +/- 34 ng/ml and 0.7 +/- 0.5 ng/ml, and for PMN-E 68 +/- 14 mu g/ml and 0.7 +/- 0.1 mu g/ml, respectively. Standard surgical procedures reduced the intra-abdominal concentrations of cytokines and PMN-E to as low as one tenth of the pre-operative levels, Postoperatively, TNF-alpha and IL-8 levels recovered rapidly and pre-operative levels of IL-8 were reached again after 1 h and for TNF-alpha after 8 h, PMN-E concentration remained below the initial baseline within 8 h of observation, TNF-alpha concentration, but not IL-8 or PMN-E, depended on the microbiological load of the abdominal exudate (< or > 10(3) cfu/ml). There were no significant differences in the intra-abdominal or plasma levels of cytokines or PMN-E between survivors and non-survivors at any observation time. (C) 1997 Academic Press Limited.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPONTANEOUS BACTERIAL PERITONITIS; ABDOMINAL-SURGERY; ORGAN FAILURE; ASCITIC FLUID; TNF-ALPHA; EXPRESSION; SYNTHESIZE; CYTOKINES; INJECTION; DIALYSIS; peritonitis; tumour necrosis factor-alpha; interleukin 8; elastase-alpha(1)-proteinase inhibitor |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50895 |
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