Wesche, H and Korherr, C and Kracht, M and Falk, W and Resch, K and Martin, MU (1997) The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). JOURNAL OF BIOLOGICAL CHEMISTRY, 272 (12). pp. 7727-7731. ISSN 0021-9258,
Full text not available from this repository.Abstract
Interleukin-1 (IL-1) is a central mediator of the immune system involved in acute and chronic inflammatory responses, Although the sequences of two types of IL-1 receptors are known, the exact molecular events resulting in signal transduction and coupling to downstream signaling elements remain unclear, The recently cloned IL-1 receptor accessory protein (IL-1RAcP) has been suggested as a co-receptor molecule for IL-1RI, supported by the observation that its expression correlates to IL-1 responsiveness, We transfected the EL-4 subline D6/76 with IL-1RAcP cDNA, This cell line is an IL-1 non-responder expressing IL-1RI but lacking constitutive IL-1RAcP expression. The expression of IL-1RAcP in EL-4 D6/76 was sufficient to restore IL-l-induced activation of interleukin-l receptor-associated kinase and of stress-activated protein kinases, translocation of the transcription factors NF kappa B and IL-1 NF to the nucleus, and induction of IL-2 mRNA synthesis, These results proved that IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and gene expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MAMMALIAN EXPRESSION; T-CELLS; CLONING; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50968 |
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