Caesar, I and Gross, V and Roth, M and Andus, T and Schmidt, C and Raedsch, R and Weber, A and Gierend, M and Ewe, K and Scholmerich, J (1997) Treatment of active and postactive ileal and colonic Crohn's disease with oral pH-modified-release budesonide. HEPATO-GASTROENTEROLOGY, 44 (14). pp. 445-451. ISSN 0172-6390,
Full text not available from this repository.Abstract
Background/Aims: Budesonide is a glucocorticoid with a high topical anti-inflammatory but low systemic activity due to its rapid hepatic inactivation. The aim of this open, multicenter study was to investigate efficacy and safety of oral pH-modified-release budesonide in patients with active Crohn's disease of the ileum and colon and in maintaining budesonide-induced remission in. postactive Crohn's disease. Materials and Methods: 81 patients (intention-to-treat) received 3 x 3 mg budesonide/day for 6 weeks, followed by 3 x 2 mg budesonide for another 6 weeks in case of response to initial treatment. Clinical and Laboratory parameters were assessed at study entry as well as after 2, 4, 6 and 12 weeks of treatment. Results: On, an intention-to-treat basis remission. was induced in 54.3 % of 81 patients with active Crohn's disease, 71.4 % of 35 patients stayed in remission after the acute-phase treatment until the end of the trial. Typical steroid-related side effects were observed during the acute-phase treatment in only 18 % of the patients. Duration, severity and extent of disease at study entry played no significant role in the outcome of the trial, but there was a tendency towards better results during the acute-phase treatment in patients with moderate disease activity and affection of the terminal ileum and proximal colon. Conclusion: Budesonide could be an alternative to conventional steroid treatment in patients with active Crohn's disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DRUG-TREATMENT; budesonide; topical steroids; Crohn's disease |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/50995 |
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