Nöth, U. and Morrissey, S. P. and Deichmann, R. and Jung, S. and Adolf, H. and Haase, A. and Lutz, J. (1997) Perfluoro-15-crown-5-ether labelled macrophages in adoptive transfer experimental allergic encephalomyelitis. ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY, 25 (3). pp. 243-254. ISSN 1073-1199, 1532-4184
Full text not available from this repository.Abstract
In this serial in,lire study, macrophages labelled with perfluoro-15-crown-5-ether (15C5) were monitored in rats after inducing adoptive transfer experimental allergic encephalomyelitis (AT-EAE). AT-EAE is an animal model of multiple sclerosis and is characterized by inflammatory infiltrates in the central nervous system (CNS) and breakdown of the blood-brain-barrier, A particular feature of AT-EAE are macrophage infiltrates. Purpose of this study was to monitor the invasive and evasive phase of the macrophages in AT-EAE by using 3-dimensional 19F magnetic resonance imaging (3D 19F-MRI). In the early stage of the disease, a much stronger 19F-signal intensity was observed in AT-EAE-rats than in healthy control rats in the tissue adjacent to CNS regions severely affected by inflammatory infiltrates, and thereafter the 19F-signal intensity was decreasing over the time. However, no 19F-signal could be observed in the CNS itself neither in AT-EAE-rats nor in control rats. According to these findings it is assumed that we monitored the evasion of the macrophages from the region of inflammation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MULTIPLE-SCLEROSIS; OXYGEN-TENSION; BLOOD; PERFLUOROCHEMICALS; EMULSIONS; SPLEEN; SYSTEM; LIVER; MRI |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 May 2023 08:26 |
| Last Modified: | 24 May 2023 08:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51124 |
Actions (login required)
 |
View Item |
