Korherr, C and Hofmeister, R and Wesche, H and Falk, W (1997) A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling. EUROPEAN JOURNAL OF IMMUNOLOGY, 27 (1). pp. 262-267. ISSN 0014-2980,
Full text not available from this repository.Abstract
Interleukin-1 (IL-1) is a central molecule in inflammation and immune responses whose pleiotropic activities are mediated by the type I IL-1 receptor (IL-1RI). The IL-1RI alone on the cell surface is silent after binding of the ligand. We show that the recently identified IL-1RI accessory protein (IL-1RAcP) converts the silent into a fully functional IL-1RI complex. Although transfection of IL-1RAcP into IL-1RAcP-deficient EL4D6/76 cells did not alter the binding kinetics or dissociation constants of the I-125-labeled IL-1 alpha/IL-1RI complex, a very early event, internalization of the activated receptor complex, and a late event, IL-1-stimulated IL-2 production, were successfully restored. Therefore, recruitment of IL-1RAcP is a critical early step in the signaling cascade mediated by the IL-1RI activation complex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR; II RECEPTOR; T-CELLS; IL-1; INTERNALIZATION; ACTIVATION; ANTAGONIST; EXPRESSION; ENDOCYTOSIS; AGONIST; interleukin-1; interleukin-1 receptor; interleukin-1 receptor accessory protein; signaling; internalization |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51184 |
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