Stocker, S and Knuchel, R and Sroka, R and Kriegmair, M and Steinbach, P and Baumgartner, R (1997) Wavelength dependent photodynamic effects on chemically induced rat bladder tumors following intravesical instillation of 5-aminolevulinic acid. JOURNAL OF UROLOGY, 157 (1). pp. 357-361. ISSN 0022-5347,
Full text not available from this repository.Abstract
Purpose: The aim of the study was to determine photodynamic effects in chemically induced rat bladder tumors after intravesical instillations of 5-aminolevulinic acid (5-ALA) and PDT-dependence on laser wavelength and Light dose. Material and Methods: Following intravesical instillation of a 5-ALA solution (40 mg 5-ALA in isotonic saline and sodium-bicarbonate) rat bladder tumors have been treated with integral irradiation using laser light at wavelengths of lambda = 630 nm and lambda = 635 nn in a light dose range of 15 to 100 J/cm(2). Results: A significantly higher amount of necrosis including damage of normal urothelium was obtained in rat bladder tumors using laser Light at lambda = 635 nm. Conclusions: For 5-ALA assisted photodynamic treatment of superficial bladder cancer in patients the irradiation wavelength of lambda = 635 nm is recommended.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THERAPY; CANCER; bladder cancer; 5-aminolevulinic acid; protoporphyrin IX; photodynamic therapy |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51223 |
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