Müller, Klaus (1996) Antipsoriatic anthrones: Aspects of oxygen radical formation, challenges and prospects. GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 27 (8). pp. 1325-1335. ISSN 0306-3623
Full text not available from this repository.Abstract
1. Antipsoriatic anthrones are among the most commonly used topical agents for the treatment of psoriasis. 2. These drugs generate reactive oxygen species during their auto oxidation under physiological conditions. 3. Recent studies have indicated that activation of molecular oxygen by anthrones may play a critical role in their mechanism of action at the molecular level. 4. This article summarizes the evidence pointing toward the significance of oxygen activation and radical formation in the antipsoriatic action and induction of skin inflammation of anthrones. 5. Also, the role of oxygen radical formation in the development of novel anthrones devoid of inflammatory and staining properties is discussed. Copyright (C) 1996 Elsevier Science Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anthralin; anthrones; antiproliferative action; dithranol; free radicals; lipoxygenase inhibition; psoriasis; reactive oxygen species; skin inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy |
| Depositing User: | Petra Gürster |
| Date Deposited: | 12 Nov 2024 09:11 |
| Last Modified: | 12 Nov 2024 09:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51295 |
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