Putz, EF and Mannel, DN (1996) A role for L-selectin in monocyte activation by Jurkat tumour cells. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 44 (6). pp. 556-564. ISSN 0300-9475, 1365-3083
Full text not available from this repository.Abstract
Monocytes and macrophages can distinguish between tumour cells and non-malignant cells of the same cell type. The surface structures mediating tumour cell recognition and tumour cell-induced cytokine production by monocytes ar macrophages are still poorly characterized, The authors previously described N-linked sialic acid-containing carbohydrates associated with CD2 of the CD4(+) tumour cell line Jurkat which induced tumour necrosis factor (TNF) secretion by human monocytes. In this report the authors demonstrate a role for monocytic L-selectin in this process, Mannose-6-phosphate, an inhibitor of L-selectin binding, blocked CD2-induced TNF production whereas other ligands for L-selectin (the monomeric monoclonal antibody to L-selectin, DREG-200; inositol hexaphosphoric acid heparin) amplified CD2-induced secretion of TNF. Polyvalent L-selectin ligands as soluble monoclonal antibody (MoAb) DREG-56, the cross-linked MoAb DREG-200. and the marine algal polysaccharide fucoidin induced TNF production without addition of CD2. Jurkat-CD2 is associated with sialyl Lewis X-related carbohydrates which differ in their expression or composition from that of thr non-stimulatory CD2 from non-malignant T cells, Taken together the data presented in this report suggest that - at least in the case of Jurkat-CD2 - L-selectin is involved in monocyte activation by tumour typical carbohydrate structures.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SIALYL-LEWIS-X; HIGH ENDOTHELIAL VENULES; NECROSIS-FACTOR-ALPHA; CARBOHYDRATE ANTIGENS; ADHESION MOLECULES; HUMAN NEUTROPHILS; MACROPHAGES; EXPRESSION; LIGAND; RECEPTOR; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51329 |
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