Frohlich, D and Rothe, G and Schwall, B and Schmitz, G and Hobbhahn, J and Taeger, K (1996) Thiopentone and propofol, but not methohexitone nor midazolam, inhibit neutrophil oxidative response to the bacterial peptide FMLP. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 13 (6). pp. 582-588. ISSN 0265-0215,
Full text not available from this repository.Abstract
The effects of different anaesthetics on the neutrophil oxidative response in vitro are compared. Neutrophils were stimulated with small amounts of the bacterial peptide N-formyl-L-methionyl-L-leucyl-phenylalanine as a physiological, receptor-dependent stimulus. A new flow cytometry-based method capable of detecting the small amounts of H2O2 generated by neutrophils in a heterogenous all-or-none response following submaximal stimulation with N-formyl-L-methionyl-L-leucyl-phenylalanine was used. Propofol and thiopentone suppressed the respiratory burst significantly (P<0.05 and P<0.01) in therapeutic concentrations, while midazolam and methohexitone inhibited significantly (P<0.01) only at concentrations greater than the therapeutic range. Impairment of the neutrophil response was primarily because of a reduction in the number of neutrophils participating in the respiratory burst and not of a proportional decrease of the fluorescence of all neutrophils.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LEUKOCYTES IN-VITRO; GRANULOCYTE FUNCTION; ANESTHETIC AGENTS; ESCHERICHIA-COLI; PHAGOCYTOSIS; EXPRESSION; PULMONARY; RECEPTORS; INVITRO; leukocytes, neutrophils, respiratory burst; anaesthetics, iv, thiopentone, methohexitone, midazolam, propofol, gamma-hydroxybutyric acid |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51372 |
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