Schmid, C and DellaBruna, R and Schricker, K and Bachmann, S and Kurtz, A (1996) Zonal expression of angiotensin II-AT(1)-receptor genes in rat kidneys. EXPERIMENTAL NEPHROLOGY, 4 (6). pp. 322-329. ISSN 1018-7782,
Full text not available from this repository.Abstract
This study aimed to examine the relative distribution of ANGII-AT(1)-receptor gene expression in different zones of the rat kidney, namely the glomeruli, cortex (CO), outer and inner stripes of outer medulla (OSOM and ISOM, respectively) and inner medulla (IM). By RNAse protection we found a ratio for the overall abundance of AT(1) mRNA of 1, 0.68, 0.52, 0.86 and 0.46 for glomeruli, CO, OSOM, ISOM and IM, respectively. The intrazonal proportion of AT(1a) and AT(1b) mRNA was determined by RT-PCR, which yielded values for the ratio AT(1a)/AT(1b) of 1.1, 4.7, 4.4, 3.7 and 1.9 for glomeruli, CO, OSOM, ISOM, and IM, respectively. These findings suggest a zonal heterogeneity in the expression of AT(1)-receptor genes such that the highest expression is found in glomeruli and ISOM, whilst the papilla shows the lowest level of expression. Moreover, there appears to exist a corticopapillary gradient for the relative expression of AT(1a) and AT(1b)-receptor genes such that the preponderance of AT(1a)-receptor gene expression decreases into a papillary direction. Within the CO glomeruli appear as an isle of AT(1b) receptors of relatively high expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RECEPTOR MESSENGER-RNA; II RECEPTOR; LOCALIZATION; SUBTYPES; CDNA; IDENTIFICATION; CLONING; CELLS; angiotensin II-receptor subtypes; gene expression; glomeruli; renal cortex; outer medulla; inner medulla |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51374 |
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