Streit, Fabian and Akdeniz, Ceren and Haddad, Leila and Kumsta, Robert and Entringer, Sonja and Frank, Josef and Yim, Ilona S. and Zaenkert, Sandra and Witt, Stephanie H. and Kirsch, Peter and Rietschel, Marcella and Wuest, Stefan (2017) Sex-specific association between functional neuropeptide S receptor gene (NPSR1) variants and cortisol and central stress responses. PSYCHONEUROENDOCRINOLOGY, 76. pp. 49-56. ISSN 0306-4530,
Full text not available from this repository. (Request a copy)Abstract
The brain neuropeptide S (NPS) system has recently generated substantial interest and may be of major relevance for central stress regulation. The NPS receptor (NPSR1) is highly expressed in the limbic system, exogenous NPS exerts pronounced anxiolytic and fear-attenuating effects in rodents and extensive close crosstalk between the NPS system and the hypothalamic-pituitary-adrenal (HPA) axis has been demonstrated. In humans, associations between NPSR1 variants and anxiety and panic disorder, as well as amygdala responsiveness to fear- relevant faces and prefrontal cortex activity in a fear conditioning paradigm have been reported. Moreover, a NPSR1 sequence variant was found to be associated with cortisol stress responses in males. (C) 2016 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PITUITARY-ADRENAL AXIS; SOCIAL STRESS; ANXIETY DISORDERS; PANIC DISORDER; PSYCHOSOCIAL STRESS; AMYGDALA; DISEASE; SYSTEM; HUMANS; BRAIN; |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 19 Feb 2019 09:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/514 |
Actions (login required)
 |
View Item |
