The activity of the gluconate-H+ symporter of Schizosaccharomyces pombe cells is down-regulated by D-glucose and exogenous cAMP

Caspari, Thomas and Urlinger, Stefanie (1996) The activity of the gluconate-H+ symporter of Schizosaccharomyces pombe cells is down-regulated by D-glucose and exogenous cAMP. FEBS LETTERS, 395 (2-3). pp. 272-276. ISSN 0014-5793, 1873-3468

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Abstract

Schizosaccharomyces pombe cells take up D-gluconate, as an alternative carbon source for growth, during glucose starvation or when cultured on glycerol-containing medium, Gluconate uptake is not detectable while cells are growing logarithmically on glucose. The addition of D-glucose as well as its non-metabolizable analogues to glycerol-grown cells causes an immediate loss of gluconate transport within 1 min. The reversible down-regulation of the gluconate carrier occurs after glucose has been internalized. This regulation is triggered not only by D-glucose but also by extracellular cAMP even in the absence of the cAMP-dependent protein kinase (PKA1).

Item Type: Article
Uncontrolled Keywords: DEPENDENT PROTEIN-KINASE; SUGAR PHOSPHOTRANSFERASE SYSTEM; CYCLIC-AMP; SACCHAROMYCES-CEREVISIAE; CATABOLITE INACTIVATION; INDUCER EXCLUSION; SIGNALING PATHWAY; YEAST; ACTIVATION; PHOSPHOENOLPYRUVATE; gluconate transport; cAMP; carrier regulation; Schizosaccharomyces pombe
Subjects: 500 Science > 580 Botanical sciences
Divisions: Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften > Lehrstuhl für Zellbiologie und Pflanzenphysiologie (Prof. Dr. Klaus Grasser)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 21 Jun 2023 10:26
Last Modified: 21 Jun 2023 10:26
URI: https://pred.uni-regensburg.de/id/eprint/51412

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