Bielmeier, P. and Kaiser, A. and Gust, R. and Wiegrebe, Wolfgang (1996) 1,3-diphenylpropane-1,3-diamines .10. Synthesis and biochemical evaluation of highly substituted 1,3-diphenylpropane-1,3-diamines and preparation of their Pt(II) complexes. MONATSHEFTE FUR CHEMIE, 127 (10). pp. 1073-1080. ISSN 0026-9247, 1434-4475
Full text not available from this repository.Abstract
The ligands of the title complexes 1 and 2 were prepared from the pertinent chalcone 5 and hydrazine hydrate, followed by N-N cleavage. The estrogenic activity of the diamines 11 and 12 was determined by measuring the RBA values (calf uterine cytosol) and by a luciferase test in MCF 7-2a cells. The compounds are by far less active than Schonenberger's most active compound ([meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethane-1,2-diamine]dichloro-platinum(II), 3).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BINDING; RING; 1,3-diphenylpropane-1,3-diamines; receptor binding affinity; estrogenic activity |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jun 2023 09:58 |
| Last Modified: | 22 Jun 2023 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51450 |
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