Bucher, Michael and Sandner, Peter and Wolf, Konrad and Kurtz, Armin (1996) Cobalt but not hypoxia stimulates PDGF gene expression in rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 271 (3). E451-E457. ISSN 0193-1849, 1522-1555
Full text not available from this repository.Abstract
Cobalt but not hypoxia stimulates PDGF gene expression in rats. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E451-E457, 1996.-This study was done to investigate the influence of different forms of acute tissue hypoxia on the expression of platelet-derived growth factor (PDGF) A chain (PDGF-A) and PDGF B chain (PDGF-B) genes in different rat organs. We found that acute normobaric hypoxia (8% O-2), carbon monoxide inhalation (0.1% CO), or lowering the hematocrit to 12% for 6 h had no effect on PDGF-A or PDGF-B gene expression in lung, heart, kidney, and liver of Sprague-Dawley rats. Subcutaneous administration of cobaltous chloride dose dependently increased PDGF-B mRNA by 125% in lungs, by 60% in kidneys, but not in heart and liver. These findings suggest that acute tissue; hypoxygenation is not a significant stimulus for PDGF-A and PDGF-B gene expression in these major rat organs. Cobalt appears to cause a tissue-specific increase of PDGF-B gene expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SMOOTH-MUSCLE CELLS; FACTOR-B-CHAIN; GROWTH-FACTOR; ALVEOLAR MACROPHAGES; OXYGEN-TENSION; MESSENGER-RNA; PROLIFERATION; MODULATION; RECEPTORS; ISOFORMS; growth factors; oxygen sensing; divalent metals; anemia; carbon monoxide; platelet-derived growth factor |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Jun 2023 11:00 |
| Last Modified: | 22 Jun 2023 11:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51483 |
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