Wang, Yi-Xiang J. and Schroeder, Joseph and Siegmund, Heiko and Idee, Jean-Marc and Fretellier, Nathalie and Jestin-Mayer, Gaelle and Factor, Cecile and Deng, Min and Kang, Wei and Morcos, Sameh K. (2015) Total gadolinium tissue deposition and skin structural findings following the administration of structurally different gadolinium chelates in healthy and ovariectomized female rats. QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 5 (4). pp. 534-545. ISSN 2223-4292, 2223-4306
Full text not available from this repository. (Request a copy)Abstract
Objective: To assess the retention of gadolinium (Gd) in skin, liver, and bone following gadodiamide or gadoteric acid administration. Methods: Gd was measured in skin, liver and femur bone in female rats 10 weeks after administration of 17.5 mmol Gd/kg over 5 days of Gd agents. Rat skin microscopy, energy filtering transmission electron microscopy and elemental analysis were performed, and repeated after receiving the same dosage of gadodiamide in rats with osteoporosis induced with bilateral ovariectomy (OVX). The OVX was performed 60 days after the last injection of gadodiamide and animals sacrificed 3 weeks later. Results: Gd concentration was 180-fold higher in the skin, 25-fold higher in the femur, and 30-fold higher in the liver in rats received gadodiamide than rats received gadoteric acid. The retention of Gd in the skin with gadodiamide was associated with an increase in dermal cellularity, and Gd encrustation of collagen fibers and deposition inside the fibroblasts and other cells. No differences in Gd concentration in liver, skin, and femur were observed between rats receiving gadodiamide with or without OVX. Conclusions: Gd tissue retention with gadodiamide was higher than gadoteric acid. Tissues Gd deposition did not alter following gadodiamide administration to ovariectomized rats.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Gadolinium (Gd); skin; ultrastructural; bone deposition; osteoporosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Jul 2019 13:00 |
| Last Modified: | 03 Jul 2019 13:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5155 |
Actions (login required)
 |
View Item |
