Wiegrebe, W. and Kammermeier, T. and Kaiser, A. and Bielmeier, P. (1996) Platinum complexes of 1,3-diphenylpropane-1,3-diamines-cytostatic compounds? CHEMICKE LISTY, 90 (8). pp. 502-514. ISSN 0009-2770, 1213-7103
Full text not available from this repository.Abstract
One of the drug-therapeutic approaches to cancer treatment is aimed at DNA modification by the application of platinum(II) complexes. The diastereoselective synthesis of 1,3-diphenylpropane-1,3-diamines and their Pt complexes are described. The compounds were tested for cytostatic activity at the estrogen-independent MDA-MB 231 mammary tumor cell line. The mechanism of action and the structure-function relationship of these potential drugs are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-INHIBITING ACTIVITY; RECEPTOR AFFINITY |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Wiegrebe |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Apr 2025 09:58 |
| Last Modified: | 24 Apr 2025 09:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51555 |
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