Schweikl, Helmut and Schmalz, Gottfried and Göttke, C. (1996) Mutagenic activity of various dentine bonding agents. BIOMATERIALS, 17 (14). pp. 1451-1456. ISSN 0142-9612, 1878-5905
Full text not available from this repository.Abstract
The potential mutagenicity of bonding agents of the new generation was characterised by employing an in vitro gene mutation assay. Eight different components of three dentine bonding systems (Scotchbond Multi Purpose, Prisma Universal Bond 3 and C&B Metabond) were tested in the Ames test using four different Salmonella strains (TA97a, TA98, TA100 and TA102). The materials were eluted in dimethyl sulphoxide and physiological saline; aliquots of the serially diluted eluates were then used in the standard plate incorporation assay. No mutagenic effects were found with Scotchbond Multi Purpose primer and adhesive, Prisma Universal Bond 3 primer, and C&B Metabond base, powder and activator. However, the glutaraldehyde-containing Prisma Universal Bond 3 adhesive elicited a strong mutagenic effect in S. typhimurium strain TA102. Mutation rates caused by dimethyl sulphoxide eluates as well as physiological saline eluates were about five times higher than solvent control values. A mutagenic effect was also observed with C&B Metabond catalyst, especially in strain TA97a when the material was eluted in physiological saline. Both mutagenic responses were not influenced by a metabolically active microsomal fraction from rat liver, We consider the results observed in the Ames test as a first indication of possible mutagenic activity in higher organisms. Therefore, the materials are currently under further investigation using a quantitative in vitro mammalian cell mutation assay. (C) 1996 Elsevier Science Limited
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SALMONELLA MICROSOME TEST; A.T BASE-PAIRS; OXIDATIVE MUTAGENS; INVITRO; GLUTARALDEHYDE; CHEMICALS; ASSAY; STRENGTHS; TOXICITY; SYSTEMS; dentine bonding; mutagenicity; Ames test; Salmonella typhimurium |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie > Prof. Dr. rer. nat. Helmut Schweikl |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2023 05:19 |
| Last Modified: | 05 Jul 2023 05:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51606 |
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