Harders, A and Kakarieka, A and Braakman, R and Hardenack, M and Schmieder, K and Trost, HA and Hellwig, H and Buchholz, EM and Klein, T and Peters, R and Zierski, J and Veelken, J and Gilsbach, JM and Mayfrank, L and Bassiouni, H and Brawanski, A and Holzschuh, M and Hassler, WE and Rohde, V and Ziebell, P and Emonds, N and Markakis, E and Kolenda, H and Zimmerer, B and Scharphuis, T and Eggert, HR and Wilkowski, A and May, JW and Faulhauer, K and Lauer, J and Paulus, J and Schoche, J and Raabe, A and Salger, D and Schibalski, G and Burkert, W and Rainov, N and Heidecke, V and Hamm, K and Grote, EH and Buchholz, R and Morgalla, M and Meinig, G and Leyendecker, K and Schuerhoff, W and Wassmann, D and Moskopp, D and vonWild, K and Schutze, M and Schonmayr, R and Busch, C and Wallenfang, T and Suadicani, A and Fussler, H and Schakel, EH and Beneke, M (1996) Traumatic subarachnoid hemorrhage and its treatment with nimodipine. JOURNAL OF NEUROSURGERY, 85 (1). pp. 82-89. ISSN 0022-3085, 1933-0693
Full text not available from this repository.Abstract
A prospective. randomized, double-blind. placebo-controlled study of nimodipine used to treat traumatic subarachnoid hemorrhage (tSAH) was conducted in 21 German neurosurgical centers between January 1994 and April 1995. One hundred twenty-three patients with tSAH appearing on initial computerized tomography (CT) scanning were entered into the study. Requirements for inclusion included age between 16 and 70 and admission into the study within 12 hours after head injury, regardless of the patient's level of consciousness. Eligible patients received either a sequential course of intravenous and oral nimodipine or placebo treatment for 3 weeks. Patients were closely monitored using clinical neurology, computerized tomography, laboratory, and transcranial Doppler ultrasound parameters. Patients treated with nimodipine had a significantly less unfavorable outcome (death, vegetative survival, or severe disability) at 6 months than placebo-treated patients (25% us. 46%, p = 0.02). The relative reduction in unfavorable outcome in the nimodipine-treated group was even higher (55%, p = 0.002) when only patients who complied with the protocol were considered.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; CEREBRAL BLOOD-FLOW; VASOSPASM; COMA; INJURY; TRIAL; SCALE; head injury; subarachnoid hemorrhage; computerized tomography; vasospasm; nimodipine; clinical trial |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51618 |
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