Dobner, Thomas and Horikoshi, Nobuo and Rubenwolf, Susanne and Shenk, Thomas (1996) Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. SCIENCE, 272 (5267). pp. 1470-1473. ISSN 0036-8075, 1095-9203
Full text not available from this repository.Abstract
The adenovirus E4orf6 protein is shown here to interact with the cellular tumor suppressor protein p53 and to block p53-mediated transcriptional activation. The adenovirus protein inhibited the ability of p53 to bind to human TAF(II)31, a component of transcription factor IID (TFIID). Earlier work demonstrated that the interaction of p53 with TAF(II)31 involves a sequence near the NH2-terminus of p53, whereas the E4orf6-p53 interaction occurs within amino acids 318 to 360 of p53. Thus, the E4orf6 protein interacts at a site on p53 distinct from the domain that binds to TAF(II)31 but nevertheless inhibits the p53-TAF(II)31 interaction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LATE GENE-EXPRESSION; WILD-TYPE; DNA-BINDING; EARLY REGION-4; TRANSFORMED-CELLS; PROTEIN; SEQUENCE; ANTIGEN; DOMAIN; TRANSACTIVATION |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2023 07:48 |
| Last Modified: | 05 Jul 2023 07:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51646 |
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