Selmer, Thorsten and Hallmann, Armin and Schmidt, Bernhard and Sumper, Manfred and von Figura, Kurt (1996) The evolutionary conservation of a novel protein modification, the conversion of cysteine to serinesemialdehyde in arylsulfatase from Volvox carteri. EUROPEAN JOURNAL OF BIOCHEMISTRY, 238 (2). pp. 341-345. ISSN 0014-2956
Full text not available from this repository.Abstract
A novel post-translational protein modification has recently been described in two human sulfatases, by which a cysteine is replaced by a serinesemialdehyde (2-amino-3-oxopropionic acid) residue [Schmidt, B., Selmer, T., Ingendoh, A. & von Figura, K. (1995) Cell 82, 271-278]. This cysteine is conserved among all known eukaryotic sulfatases. Here we report the presence of this modification in arylsulfatase from the green alga Volvox carteri. The evolutionary conservation of this novel protein modification between sulfatases of V. carteri and man lends further support to the assumption that this modification is required for the catalytic activity of sulfatases and may be present in all sulfatases of eukaryotic origin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FULL-LENGTH CDNA; STEROID-SULFATASE; NUCLEOTIDE-SEQUENCE; EXPRESSION; CLONING; GENE; DEFICIENCY; 2-amino-3-oxopropionic acid; arylsulfatases; multiple-sulfatase deficiency; Volvox carteri |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Alumni or Retired > Prof. Dr. Manfred Sumper |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2023 09:56 |
| Last Modified: | 05 Jul 2023 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51663 |
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