Schricker, Karin and Kurtz, Armin (1996) Blockade of nitric oxide formation inhibits the stimulation of the renin system by a low salt intake. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 432 (2). pp. 187-191. ISSN 0031-6768, 1432-2013
Full text not available from this repository.Abstract
This study aimed to investigate the possible involvement of endothelial autacoids such as nitric oxide or prostaglandins in the well-known stimulatory effect of a low salt intake on renin secretion and renin gene expression in the kidney. To this end, plasma renin activity (PRA) and kidney renin mRNA levels were determined in male Spargue-Dawley rats fed either a normal (0.6% w/w) or a low (0.03%) NaCl diet for 10 days. To inhibit nitric oxide formation, the animals received L-nitro-argininemethylester (L-NAME, 40 mg/kg twice a day), to inhibit prostaglandin formation the animals received meclofenamate (8 mg/kg twice a day) during the last 2 days. In animals fed a normal salt diet, L-NAME decreased PRA from 6.5 to 4.9 ng angiotensin I . h(-1). ml(-1) and decreased renin mRNA levels by about 15%. Meclofenamate did not change PRA or renin mRNA in animals fed on normal salt diet. In vehicle-treated animals fed a low salt diet, PRA increased from 6.5 to 20.2 ng ANGI . h(-1). ml(-1) and renin mRNA levels increased by 100%. Meclofenamate treatment did not alter these changes of PRA and renin mRNA during the intake of a low salt diet. In animals treated with L-NAME, PRA increased to only 7.2 ng ANGI . h(-1). ml(-1) and renin mRNA increased by 20%. These findings indicate that inhibition of nitric oxide formation but not of prostaglandin formation substantially attenuates the stimulatory effect of a low salt intake on the renin system, suggesting that nitric oxide is required for this process.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RELEASE; SECRETION; GENE; DOGS; L-NAME; RAAS; salt diet |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2023 05:35 |
| Last Modified: | 06 Jul 2023 05:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51687 |
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