Hoffman, R and Paper, DH and Donaldson, J and Vogl, H (1996) Inhibition of angiogenesis and murine tumour growth by laminarin sulphate. BRITISH JOURNAL OF CANCER, 73 (10). pp. 1183-1186. ISSN 0007-0920,
Full text not available from this repository.Abstract
LAM S5 is a polysulphated derivative of the glucan laminarin that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P=0.01).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PENTOSAN POLYSULFATE; HEPARIN FRAGMENT; POLYSACCHARIDE; CORTISONE; MICE; angiogenesis; laminarin sulphate; anti-tumour |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51724 |
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