Bruttger, Julia and Karram, Khalad and Woertge, Simone and Regen, Tommy and Marini, Federico and Hoppmann, Nicola and Klein, Matthias and Blank, Thomas and Yona, Simon and Wolf, Yochai and Mack, Matthias and Pinteaux, Emmanuel and Mueller, Werner and Zipp, Frauke and Binder, Harald and Bopp, Tobias and Prinz, Marco and Jung, Steffen and Waisman, Ari (2015) Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. IMMUNITY, 43 (1). pp. 92-106. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
During early embryogenesis, microglia arise from yolk sac progenitors that populate the developing central nervous system (CNS), but how the tissue-resident macrophages are maintained throughout the organism's lifespan still remains unclear. Here, we describe a system that allows specific, conditional ablation of microglia in adult mice. We found that the microglial compartment was reconstituted within 1 week of depletion. Microglia repopulation relied on CNS-resident cells, independent from bone-marrow-derived precursors. During repopulation, microglia formed clusters of highly proliferative cells that migrated apart once steady state was achieved. Proliferating microglia expressed high amounts of the interleukin-1 receptor (IL-1R), and treatment with an IL-1R antagonist during the repopulation phase impaired microglia proliferation. Hence, microglia have the potential for efficient self-renewal without the contribution of peripheral myeloid cells, and IL-1R signaling participates in this restorative proliferation process.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MOUSE SPINAL-CORD; HEMATOPOIETIC-CELLS; RESIDENT MICROGLIA; LANGERHANS CELLS; I RECEPTOR; BRAIN; MONOCYTES; MAINTENANCE; MACROPHAGES; PROLIFERATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2019 12:50 |
| Last Modified: | 05 Jul 2019 12:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5188 |
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