Bocchetta, M. and Huber, R. and Cammarano, P. (1996) Sensitivity of ribosomes of the hyperthermophilic bacterium Aquifex pyrophilus to aminoglycoside antibiotics. JOURNAL OF BACTERIOLOGY, 178 (6). pp. 1762-1765. ISSN 0021-9193, 1098-5530
Full text not available from this repository.Abstract
A poly(U)-programmed cell-free system from the hyperthermophilic bacterium Aquifex pyrophilus has been developed, and the susceptibility of Aquifex ribosomes to the miscoding-inducing and inhibitory actions of all known classes of aminoglycoside antibiotics has been assayed at temperatures (75 to 80 degrees C) close to the physiological optimum for cell growth. Unlike Thermotoga maritima ribosomes, which are systematically refractory to all known classes of aminoglycoside compounds (P. Londei, S. Altamura, R. Huber, K. O. Stetter, and P. Cammarano, J. Bacteriol, 170:4353-4360, 1988), Aquifex ribosomes are susceptible to all of the aminoglycosides tested (disubstituted 2-deoxystreptamines monosubstituted 2-deoxystreptamines, and streptidine compounds). The significance of this result in light of the Aquifex and Thermotoga placements in phylogenetic trees of molecular sequences is discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ELONGATION FACTOR-TU; THERMOTOGA-MARITIMA; PYROCOCCUS-WOESEI; GENE; SEQUENCES; ARCHAEAL |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie (Archaeenzentrum) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Nov 2023 09:57 |
| Last Modified: | 02 Nov 2023 09:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/51890 |
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